RESUMEN
INTRODUCTION/OBJECTIVES: To assess the utility of the computerized cognitive function assessment tool, CogEvo, as a screening tool for mild cognitive impairment in primary care, we explored the relationship between CogEvo performance, age, and the severity of cognitive dysfunction evaluated by the Mini-Mental State Examination (MMSE). METHODS: The observational cross-sectional study included 209 individuals' data (mean age 79.4 ± 8.9 years). We conducted a correlation analysis between CogEvo and MMSE scores, compared the performance among the 3 cognitive function groups (MMSE ≥ 28 group; MMSE24-27 group; MMSE ≤ 23 group) using the MMSE cut-off, and evaluated CogEvo's predictive accuracy for cognitive dysfunction through ROC analysis. RESULTS: Both total CogEvo and MMSE scores significantly decreased with age. A significant positive correlation was observed between total CogEvo and MMSE scores, but a ceiling effect was detected in MMSE performance. Significant differences were observed in the total CogEvo score, including orientation and spatial cognitive function scores, among the 3 groups. CogEvo showed no educational bias. ROC analyses indicated moderate discrimination between the MMSE ≥ 28 group and the MMSE24-27 and MMSE ≤ 23 groups. CONCLUSIONS: The computer-administered CogEvo has the advantage of not exhibiting ceiling effects or educational bias like the MMSE, and was found to be able to detect age-related cognitive decline and impairment.
Asunto(s)
Disfunción Cognitiva , Demencia , Anciano , Anciano de 80 o más Años , Humanos , Cognición , Disfunción Cognitiva/diagnóstico , Disfunción Cognitiva/psicología , Estudios Transversales , Demencia/psicología , EscolaridadRESUMEN
Polarization volume gratings (PVGs) based on chiral nematic liquid crystals offer a great potential as polarization-dependent holographic optical elements, but it is not easy to fabricate PVGs with varying pattern periods in the transverse plane. Here, we fabricate a PVG with an in-plane gradient of the pattern period by performing two-beam interference photoalignment on a flexible polyimide substrate. The pattern period varies depending on the local interference angle, which is controlled by the bent shape of the flexible substrate. We demonstrate fabrication of a PVG with a linearly graded sub-micrometer period, showing the potential of the proposed method to fabricate designer PVGs.